1. Tumor Lysis Syndrome

Roman Štoudek, MD, Kristýna Polášková, MD, PhD

Time limit: 5 min.

Tumor Lysis Syndrome
Select the laboratory abnormalities that form the criteria for the diagnosis of TLS. Two or more laboratory signs within 3 days before or within 7 days after initiation of cytotoxic therapy are required for a diagnosis of TLS.

1. Uric acid > 476 µmol/l or > 25% increase from baseline 2. Phosphorus > 2.1 mmol/l or > 25% increase from baseline 3. Leukocytosis > 100 thousand/μl or > 25% decrease from baseline 4. Thrombocytopenia < 50 thousand/μl or > 25% decrease from baseline 5. Anaemia: Hb < 70 g/l or > 25% decrease from baseline 6. Ionised calcium > 1.75 mmol/l or > 25% increase from baseline 7. Potassium > 6 mmol/l or > 25% increase from baseline