You are an anaesthesiologist on duty at the Children's Hospital and you are called to the surgical ward for a consult. On arrival, you learn that the patient is Anna N. (10), who is admitted and indicated for an acute laparoscopic appendectomy under general anaesthesia. She has symptoms of peritoneal irritation and has vomited repeatedly. The documentation states that the patient suffers from MELAS disease.
This disease manifest itself as...?